Study: Cancer drug substitute linked to higher rate of relapse

(CBS News) Abby Alonzo was 10 when she was diagnosed in 2009 with Hodgkin's lymphoma, a cancer of the immune system. With proper treatment, 90 percent of patients survive.

"It wasn't as hard for me as I think it as it was on my mom and my brother and my dad," Abby says.

Abby began a seven-drug regimen. But in 2010, doctors told Abby's mother, Katie, there was a nationwide shortage of one of the medicines -- mechlorethamine.

"I started to get a little hysterical, 'Why is it not available?'" says Katie.

In 2010, 23 cancer drugs had shortages. Reasons include manufacturing problems and low profit margins for the drugs, which became mostly generic, and therefore less expensive, than brand-name.

"There is really nothing you can do," Katie says. "You do what your doctor tells you to do, you take what medications your doctor tells you to take, and you pray that it works. And if one of those medications isn't available, you just take, you know, the next-best thing."

Doctors thought the next-best thing for patients like Abby was a drug called cyclophosphamide.

Life-saving cancer drugs for children stuck in federal legislative limbo

But a new study in the New England Journal of Medicine showed 88 percent treated with the original drug were cancer-free after two years -- compared to only 75 percent of those receiving the replacement drug.

"This is the first study to clearly show that when we substitute one drug for what we think is just an equally good drug, that's not always going to be the case. So it's demonstrating a negative impact on patients," says Dr. Richard Gilbertson, the director of cancer care at St. Jude Children's Research Hospital.

Abby was one of the patients who relapsed. She then needed a bone marrow transplant, radiation and more chemotherapy. Right now, she shows no signs of cancer.

"What if I relapsed again? Or what if something else happens? You know, it is just really scary, that part," Abby says.

The original drug in the study is finally available again after almost three years. But there are still 13 drugs used in cancer therapy, and a total of 100 on the FDA shortage list.

Congress passed legislation last July giving the FDA more authority to deal with cancer drug shortages. That new law has made a big difference, and the key provision is the requirement that drug manufacturers let the FDA know when there's an impending shortage.

Since that law was passed, there has been a doubling of those notifications, so the FDA can increase imports from abroad and tell other manufacturers in the United States to step up production.

Another provision in that law is that the FDA set up a task force looking at other possible solutions to the drug shortage crisis, and they're required to submit that report to Congress by this coming July.

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WH Lashes Out at 'Congressional Stupidity'


With only days to come up with a deal to avoid the fiscal cliff, the White House said “congressional stupidity” was damaging the economy but that an agreement could be reached if Republican leaders don’t get in the way.


President Obama cut his Hawaiian vacation short and headed back to Washington today while the Senate is scheduled to reconvene on Thursday. House Speaker John Boehner, R-Ohio, said previously that he would give House members a 48-hour notice of any upcoming vote, which means that the soonest the House could consider a bill would be Saturday — just two days before a deadline to make a deal or trigger a rise in taxes and steep budget cuts.


Boehner and other GOP leaders issued a statement today following a conference call saying: “The House has acted on two bills which collectively would avert the entire fiscal cliff if enacted. Those bills await action by the Senate.  If the Senate will not approve and send them to the president to be signed into law in their current form, they must be amended and returned to the House.”


While Boehner put the onus on the president and Senate Majority Leader Harry Reid, a White House official used testy language to  put the responsibility back on Boehner and Senate Minority Leader Mitch McConnell.


“What we need is for the Senate Minority Leader not to block a vote and for Boehner to allow a vote,” a White House official told ABC News. “The hits to our economy aren’t coming from outside factors, they’re coming from congressional stupidity.”


Reid’s plan would serve as a Democratic counterpart to Boehner’s plan B, which failed to gain enough support for a vote last week. Boehner left the ball in the Senate’s court after withdrawing  his plan Thursday.


Any plan from Reid is expected to include extending the Bush tax cuts for Americans making $250,000 or less.


Related: What if Bush tax cuts expire?


This has been a sticking point for the left and the right throughout discussions. Democrats believe that lower- and middle-class families should keep the  tax cut, while letting it expire for households making more than $250,000. Republicans counter that no Americans should be forced to pay higher taxes come Jan. 1, though Boehner’s plan would have required those making more than $1 million to lose the cut.


Reid could also propose cuts to tax deductions to generate more federal revenue.


Related: Can the mortgage deduction survive the fiscal cliff?


Michael Ettlinger, vice president for economic policy at the liberal think tank Center for American Progress, said that would make his plan very similar to Obama’s.


“I think this is likely to go smaller more than bigger as they try to gather votes in the Senate,” Ettlinger told ABC News Wednesday. “The Democratic vision of things is fairly clear. Where the Senate Republicans are willing to go is less so. That’s going to be the issue.”


Dan Holler of conservative policy advocacy group Heritage Action for America expects the plan to include an extension of unemployment benefits, something he says would be “extremely counterproductive for the economy.”


Democrats “see it as one of the most stimulative things you can do,” Holler told ABC News Wednesday. “Heritage has great research to go ahead and say this doesn’t really help.”


Related: Fiscal Cliff negotiators search for cuts without sacrifice.


In addition to an immediate measure to stop taxes from going up, Holler suggested there would be a mechanism to compel leaders to do more further down the road, a method he said has not historically been effective at reducing the deficit.


“I think Republicans are going to look at the entire package skeptically,” Holler said of Reid’s expected plan.


Boehner press secretary Michael Steel told ABC News the speaker’s office “will take a look” at Reid’s proposal once he brings it up for a vote or shares his ideas with the House.


Garnering consensus among both parties will be difficult for any plan now. Starbucks CEO Howard Schultz is trying to bring D.C. politicians together with every coffee cup sold in the District.


Critics have called into question  Boehner’s ability to bring his own party together.


“It seems that, in the House now, Boehner has no control over his extreme right-wing faction,” Sen. Bernie Sanders, I-Vt., said on MSNBC Wednesday. “You have, over in the House, a situation where the Republicans are saying, ‘Hey, we don’t think billionaires should pay a nickel more in taxes, but we do think there should be devastating cuts in programs that are impacting working families who are already hurting as a result of the recession.’ So that’s the problem that we have.”


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Egypt approves constitution drafted by Mursi allies


CAIRO (Reuters) - Egyptian voters overwhelmingly approved a constitution drafted by President Mohamed Mursi's allies, results announced on Tuesday showed, proving that liberals, leftists and Christians have been powerless to halt the march of Islamists in power.


Final elections commission figures showed the constitution adopted with 63.8 percent of the vote in the referendum held over two days this month, giving Mursi's Islamists their third straight electoral victory since veteran autocrat Hosni Mubarak was toppled in a 2011 revolution.


Opposition groups had taken to the streets to block what they see as a move to ram through a charter that mixes politics and religion dangerously and ignores the rights of minorities.


Mursi says the text - Egypt's first constitution since Mubarak's fall - offers enough protection for minorities, and adopting it quickly is necessary to end two years of turmoil and political uncertainty that has wrecked the economy.


"I hope all national powers will now start working together now to build a new Egypt," Murad Ali, a senior official in the Muslim Brotherhood's Freedom and Justice Party, told Reuters.


"I see this as the best constitution in Egypt's history."


In a sign that weeks of unrest have taken a further toll on the economy, the government ordered new restrictions on foreign currency apparently designed to prevent capital flight. Leaving or entering with more than $10,000 cash is now banned.


Two years since waves of unrest broke out across the Middle East and North Africa - sweeping away long-entrenched rulers in Tunisia, Libya and Yemen as well as Egypt - well-organized Islamist parties have emerged as the main beneficiaries.


Urban secularists and liberals who were behind the revolts complain that their success has been hijacked.


"We need a better constitution," said Khaled Dawood, an opposition spokesman. "It does not represent all Egyptians."


Mursi's opponents say the new constitution could allow clerics to intervene in lawmaking, while offering scant protections to minorities and women. Mursi dismisses those criticisms, and many Egyptians are fed up with street protest movements that have prevented a return to normality.


Immediately after the announcement, a small group of protesters set tires on fire and blocked traffic near the central Tahrir square, the cradle of Egypt's uprising, but there were no immediate signs of violence or major demonstrations.


Washington, which provides billions of dollars a year in military and other support for Egypt and regards it as a pillar of security in the Middle East, called on Egyptian politicians to bridge divisions and on all sides to reject violence.


"President Mursi, as the democratically elected leader of Egypt, has a special responsibility to move forward in a way that recognizes the urgent need to bridge divisions," State Department spokesman Patrick Ventrell said. He noted that many Egyptians had voiced "significant concerns" over the constitutional process.


WORSENING ECONOMY


The government says its opponents are worsening the economic crisis by prolonging political upheaval. It has pledged to impose unpopular tax increases and spending cuts to win a loan package from the International Monetary Fund.


The ban on travelling with more than $10,000 in cash followed a pledge by the central bank to take unspecified measures to protect Egyptian banks. Some Egyptians have begun withdrawing their savings in fear of more restrictions.


"I am not going to put any more money in the bank and neither will many of the people I know," said Ayman Osama, father of two young children.


He said he had taken out the equivalent of about $16,000 from his account this week and planned to withdraw more, adding that he had also told his wife to buy more gold jewellery.


The "yes" vote paves the way for a parliamentary election in about two months, setting the stage for another battle between surging Islamists and their fractious opponents.


The final result, announced by the election commission, matched - to the last decimal place - an earlier unofficial tally announced by Mursi's Muslim Brotherhood.


But the opposition said it was disappointed - it had appealed for the result to be amended to reflect what it described as major vote violations during the two-round vote.


Officials said there were no violations serious enough to change the result significantly. "We have seriously investigated all the complaints," said judge Samir Abu el-Matti of the Supreme Election Committee. The final turnout was 32.9 percent.


SENSE OF CRISIS


The referendum has sharpened painful divisions in the Arab world's most populous nation and a growing atmosphere of crisis has gripped Egypt's polarized society.


Anxiety about the economy deepened this week when Standard and Poor's cut Egypt's long-term credit rating. Prime Minister Hisham Kandil told the nation of 83 million on Tuesday the government was committed to fixing the economy.


"The main goals that the government is working towards now is plugging the budget deficit, and working on increasing growth to boost employment rates, curb inflation, and increase the competitiveness of Egyptian exports," he said.


The referendum follows Islamist victories in parliamentary and presidential elections, representing a decisive shift in a country at the heart of the Arab world where Mursi's Muslim Brotherhood was suppressed for generations by military rulers.


However, secularist and liberal opposition members hope they can organize better in time for the next parliamentary vote.


Hossam El-Din Ali, a 35-year-old newspaper vendor in central Cairo, said he agreed the new constitution would help bring some political stability but like many others he feared the possible economic austerity measures lying ahead.


"People don't want higher prices. People are upset about this," he said. "There is recession, things are not moving. But I am wishing for the best, God willing."


(Additional reporting by Patrick Werr, Tamim Elyan, Ahmed Tolba and Marwa Awad; Writing by Maria Golovnina)



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Real growth in household incomes over past 5 years despite higher inflation: MOF






SINGAPORE: Singapore's economic growth slowed significantly this year, as subdued external demand affected most sectors of the economy.

But findings from the Ministry of Finance's second issue of the Singapore Public Sector Outcomes Review (SPOR) showed that there has been real growth in household incomes over the past five years despite higher inflation.

Median monthly household incomes dipped in 2009 to S$4,850 with the economic downturn, although these remain higher than five years ago - S$4,267 in 2005.

Incomes have since risen in 2010 with the economic recovery and tighter labour market.

The review found that to keep incomes on a sustainable growth path, the skills and productivity of workers must be raised. If the goal of raising productivity by two to three per cent per year over the next decade is achieved, median real incomes should grow by about 30 per cent over 10 years.

Published once every two years, SPOR provides a perspective on how the public sector and Singapore have fared in six broad range of areas of national interest including growing incomes and fostering strong families and a cohesive society.

The review said immediate challenges remain but are being addressed and these include relieving pressure in public housing and transport infrastructure.

Beyond these, SPOR said the government must keep sight of long-term issues vital to Singapore's survival, security and success.

Public policy will also have to take into account a greater diversity of needs and interests as society evolves.

The current Our Singapore Conversation is an effort to involve many Singaporeans in gathering aspirations and hopes for Singapore's future, and ideas on how we can achieve them together.

- CNA/ck



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Stuxnet attacks Iran again, reports say




An Iranian news agency says the country successfully fended off yet another attack by the Stuxnet worm, according to reports.


The cyberattack targeted a power plant and other sites in southern Iran over the fall, the BBC and the Associated Press reported today.


Discovered in June 2010, Stuxnet is believed to be the first malware targeted specifically at critical infrastructure systems. It's thought to have been designed to shut down centrifuges at Iran's Natanz uranium enrichment plant, where stoppages and other problems reportedly occurred around that time. The sophisticated worm spreads via USB drives and through four previously unknown holes, known as zero-day vulnerabilities, in Windows.


Stuxnet is just one of several versions of malware aimed at Middle Eastern countries in the past two and a half years. Along Stuxnet, there have arisen Duqu, Gauss, Mahdi, Flame, Wiper, and Shamoon.


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AR-15 gun sales continue to spike after shootings

(CBS News) The Newtown shootings and Monday's ambush in Webster, N.Y., have fueled the debate over gun control.

While that debate intensifies, something else is spiking: Gun sales.

At gun shows across the nation this past weekend people stood in line hoping to get their hands on an AR-15, the military-style rifle used in the Newtown Connecticut school shooting.

Popular AR-15 rifle at center of gun control debate
A gun enthusiast explains his hobby
As NRA is criticized on shooting response, bullets sell

There's been a run on AR-15s at gun stores, too.

"I normally sell about 15-20 a month. I've sold about 30 in the last three days," said Rick Friedman, who owns RTSP in Randolph, N.J.

The reason, he says, is clear: "Because people want to make sure they can own them legally before they get the right taken away."

The White House said after the Newtown shooting that President Barack Obama supports a ban on assault weapons proposed by California Democratic Senator Diane Feinstein. Getting it through Congress quickly is highly unlikely, but the mere mention of a ban is enough to send sales soaring. And it's not just guns.

Brownells, the world's largest firearms supplier, says it recently sold more than three-and-a-half years worth of AR-15 magazines in three days.

Even before Newtown, sales of guns and ammunition this year were surging.

FBI background checks of potential gun buyers were up 31 percent in November 2012 over 2011.


Chuck Nesby, an instructor at Nova Firearms in Falls Church, Va., said they nearly sold out of AR-15s and high-capacity magazines after the shooting in Newtown.

Chuck Nesby, an instructor at Nova Firearms in Falls Church, Va., said they nearly sold out of AR-15s and high-capacity magazines after the shooting in Newtown.


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CBS News

In a report issued prior to Newtown, the market research firm IbisWorld, which tracks the gun industry, found "Gun enthusiasts are working themselves into a frenzy over what another four years under the Obama administration may hold for gun laws."

Chuck Nesby is an instructor at Nova Firearms in Falls Church, Va., where they nearly sold out of AR-15s and high-capacity magazines after Newtown.

"If I could I would give Sen. Feinstein and the president salesmen of the year awards."

Sen. Feinstein plans to introduce her bill to ban the sale or manufacturer of assault weapons on the first day of the new Congress in January. That's expected to trigger yet another boost in gun sales.

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Gunman Killed Firemen With Bushmaster, Left Note












A convicted killer, who shot dead two firefighters with a Bushmaster assault rifle after leading them into an ambush when they responded to a house fire he set in Western New York, left behind a typewritten note saying he wanted to "do what I like doing best, killing people," police said.


William Spengler, 62, set his home and a car on fire early Monday morning with the intention of setting a trap to kill firefighters and to see "how much of the neighborhood I can burn down," according to the note he wrote and which police found at the scene. The note did not give a reason for his actions.


Spengler, who served 18 years in prison for beating his 92-year-old grandmother to death with a hammer in 1981, hid Monday morning in a small ditch beside a tree overlooking the sleepy lakeside street in Webster, N.Y., where he lived with his sister, police said today in a news conference.


Police said they found remains in the house, believed to be that of the sister, Cheryl Spengler, 67.


As firefighters arrived on the scene after a 5:30 a.m. 911 call on the morning of Christmas Eve, Spengler opened fire on them with the Bushmaster, the same semi-automatic, military-style weapon used in the Dec. 14 rampage killing of 20 children in Newtown, Conn.




"This was a clear ambush on first responders… Spengler had armed himself heavily and taken area of cover," said Gerald Pickering, the chief of the Webster Police Department.


Armed with a Smith & Wesson .38 caliber revolver, a Mossman 12-gauge shotgun, and the Bushmaster, Spengler killed two firefighters, and injured two more as well as an off-duty police officer at the scene.


As a convicted felon, Spengler could not legally own a firearm and police are investigating how he obtained the weapons.


One firefighter tried to take cover in his fire engine and was killed with a gunshot through the windshield, Pickering said.


Responding police engaged in a gunfight with Spengler, who ultimately died, likely by a self-inflicted gunshot wound to the head.


As police engaged the gunman, more houses along Lake Ontario were engulfed, ultimately razing seven of them. Some 33 people in adjoining homes were displaced by the fire.


SWAT teams were forced to evacuate residents using armored vehicles.


Police identified the two slain firefighter as Lt. Michael Chiapperini, a 20-year veteran of the Webster Police Department and "lifetime firefighter," according to Pickering, and Tomasz Kaczowka, who also worked as a 911 dispatcher.


Two other firefighters were wounded and remain the intensive care unit at Strong Memorial Hospital in Rochester, N.Y.


Joseph Hofsetter was shot once. He sustained an injury to his pelvis and has "a long road to recovery," said Dr. Nicole A. Stassen, a trauma physician.


The second firefighter, Theodore Scardino, was shot twice and received injuries to his left shoulder and left lung, as well as a knee.



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U.N. General Assembly voices concern for Myanmar's Muslims


UNITED NATIONS (Reuters) - The U.N. General Assembly expressed serious concern on Monday over violence between Rohingya Muslims and Buddhists in Myanmar and called upon its government to address reports of human rights abuses by some authorities.


The 193-nation General Assembly approved by consensus a non-binding resolution, which Myanmar said last month contained a "litany of sweeping allegations, accuracies of which have yet to be verified."


Outbreaks of violence between ethnic Rakhine Buddhists and the Rohingyas have killed dozens and displaced thousands since June. Rights groups also have accused Myanmar security forces of killing, raping and arresting Rohingyas after the riots. Myanmar said it exercised "maximum restraint" to quell the violence.


The unanimously adopted U.N. resolution "expressing particular concern about the situation of the Rohingya minority in Rakhine state, urges the government to take action to bring about an improvement in their situation and to protect all their human rights, including their right to a nationality."


At least 800,000 Muslim Rohingyas live in Rakhine State along the western coast of Myanmar, also known as Burma. But Buddhist Rakhines and other Burmese view them as illegal immigrants from neighboring Bangladesh who deserve neither rights nor sympathy.


The resolution adopted on Monday is identical to one approved last month by the General Assembly's Third Committee, which focuses on human rights. After that vote, Myanmar's mission to the United Nations said that it accepted the resolution but objected to the Rohingyas being referred to as a minority.


"There has been no such ethnic group as Rohingya among the ethnic groups of Myanmar," a representative of Myanmar said at the time. "Despite this fact, the right to citizenship for any member or community has been and will never be denied if they are in line with the law of the land."


(Reporting By Louis Charbonneau; Editing by Paul Simao)



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Yen ticks up in Asia after easing-sparked tumble






TOKYO: The yen edged higher in Asian trade on Tuesday after tumbling on speculation that the Bank of Japan would launch more easing measures in the face of political demands for policy action.

The dollar bought 84.74 yen in Tokyo morning trade, a shade lower than 84.82 yen in New York Monday afternoon, after climbing to 85 yen, a level last breached in April 2011.

The euro fetched 111.69 yen and $1.3178 from 111.87 yen and $1.3183 in US trade.

The Japanese currency had dipped against the dollar and the euro on Monday after incoming prime minister Shinzo Abe, whose Liberal Democratic Party won a landslide national election last week, renewed calls on the Bank of Japan to take further steps to ease monetary policy.

Abe at the weekend threatened to change a law guaranteeing the central bank's independence if it did not agree to set a two-per cent inflation target as he requested in a bid to drag the country out of the deflation that has haunted its economy for years.

Tokyo markets were closed Monday for a national holiday.

Despite pessimism over divided US lawmakers reaching a deal on the fiscal cliff, dealers said the dollar could see more upward momentum after reaching a 20-month high earlier.

On Thursday, Japan's central bank expanded an asset-buying programme -- its main policy tool -- by 10 trillion yen ($119 billion) to 101 trillion yen, days after the conservative LDP won a weekend election promising to boost spending and pressure the central bank for aggressive action.

With most regional markets closed for a holiday, forex trade was expected to remain quiet on Tuesday.

- AFP/ck



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Customer claims Sprint worker said his fingers 'too fat' for iPhone



Does finger size really matter?



(Credit:
CNET)


It's possible you might put on a few pounds during this holiday season.


Might I suggest you perform additional exercises with your fingers? You know, so that they don't get too large.


This would seem to be extremely sane advice if you want to buy an iPhone from Sprint.


At least that's what one Sprint customer would have you believe. This customer says he billowed his way into his local Sprint store in order to get a replacement for his damaged
iPhone 4.


As told to Tom's Hardware, when he discovered he could get a free replacement, the customer thought this seemed like a sound value proposition.


The Sprint salesperson allegedly countered by telling the customer that the iPhone is "really a piece of s***."


I am all for creative salesmanship. This, however, seemed to go down as well as a restoration of the Mona Lisa involving acrylics and a hairbrush.


As many salespeople are, this one was apparently undeterred.


He allegedly went on to list all the many, colorful reasons why the iPhone is really, really "a piece of s***."


These included battery life, fragility, and size -- the last of which supposedly led to "your fingers are too fat for such a phone. You should get the Galaxy S3."



More Technically Incorrect



I would be stunned into emitting lava from my mouth had I not myself, with a slim-fingered witness at my side, enjoyed a somewhat similar experience at a Verizon store, where the salesperson did everything possible to unsell me an iPhone.


No, he didn't use the phrase "really a piece of s***." But he did offer that other phones were 10 times faster than the iPhone and that only Apple wants to push iPhones, Verizon doesn't.


I am sure that in neither case could the salesperson's iPooh-poohing be at all related to the amount of money the store makes (or doesn't) from the iPhone.


I have contacted Sprint to see whether the company has any comment about the digital size of customers who are eligible to buy an iPhone.


In this particular case, the transaction doesn't seem to have gone in Sprint's favor.


For the customer concluded:

"Okay [M], your nametag doesn't say 'Sprint Rep/Nutritionist' so don't tell me how I can't use the phone because of my 'fat' fingers." Fed up with his attitude and tone of condescension, I walked out, no phone in hand. I'd rather have a broken phone than to have to put up with such a rude person.


Yes, he thought the salesperson was fatheaded.


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